SimFil is a program designed to demonstrate how a lumped-parameter model of a flexible cytoskeletal filament can capture several key biophysical features of real filaments: deflection under static load, relaxation time-constant, and thermal writhing.
This code was extracted and simplified from research oriented simulations of complex cell biology behaviors in which very many flexible filaments polymerize and interact through forces with each other and with other objects.
This tutorial will briefly discuss the biophysics of each tuning criteria and show you how to determine good tuning coefficients for any set of filament, environmental, and simulation properties. In addition, pre-tuned parameter sets are provided for both actin filaments and microtubules under typical cellular conditions.
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