// first vulval model, single cell. 8june06 &Model &width 1 // Just a single cell &height 1 &numsides 4 &Network vulva1 &Nodes &ER &Location membrane &Color blue &Show on &Scale 1.0 &Type COMPLEX &XPos -10000 &YPos -10000 &endER &ERA &Location membrane &Color blue &Show on &Scale 1.0 &Type COMPLEX &XPos -10000 &YPos -10000 &endERA &ERAI &Location cyto &Color blue &Show on &Scale 1.0 &Type COMPLEX &XPos -10000 &YPos -10000 &endERAI &N &Location membrane &Color red &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &endN &dsl &Location membrane &Color red &Show on &Scale 1.0 &Type RNA &XPos -10000 &YPos -10000 &enddsl &DSL &Location membrane &Color red &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &endDSL &NDSL &Location membrane &Color red &Show on &Scale 1.0 &Type COMPLEX &XPos -10000 &YPos -10000 &endNDSL &NI &Location cyto &Color red &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &endNI &lip-1 &Location cyto &Color red &Show on &Scale 1.0 &Type RNA &XPos -10000 &YPos -10000 &endlip-1 &LIP-1 &Location cyto &Color red &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &endLIP-1 &MAPK &Location cyto &Color blue &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &endMAPK &MAPKP &Location cyto &Color blue &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &endMAPKP &dep-1 &Location cyto &Color green &Show on &Scale 1.0 &Type RNA &XPos -10000 &YPos -10000 &enddep-1 &DEP-1 &Location membrane &Color green &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &endDEP-1 &dep_ACT &Location cyto &Color green &Show on &Scale 1.0 &Type PROTEIN &XPos -10000 &YPos -10000 &enddep_ACT &endNodes &Interactions &dsl &DecayAff dsl H_dsl &Txn1Aff MAPKP K_MAPKPdsl nu_MAPKPdsl H_dsl &enddsl &DSL &DecayAff DSL H_DSL &TlnAff dsl H_DSL &DimerizeAllMembrane_AAff DSL N r_DSLN maxN &DissociationEC_Lig_Aff NDSL NDSL H_NDSL maxN maxDSL &endDSL &N &DecayRegUpAff N MAPKP H_N K_MAPKPn nu_MAPKPn H_N_min &ConstantLevelAff H_N Final_N &DimerizeAllMembrane_AAff N DSL r_DSLN maxDSL &DissociationEC_Rec_Aff NDSL H_NDSL &endN &NI &DecayAff NI H_NI &EndoIAff NI NDSL endo_NI &endNI &NDSL &DimerizeAllMembrane_BAff N DSL r_DSLN maxDSL &DissociationEC_Com_Aff NDSL H_NDSL &EndoEAff NI NDSL endo_NI &endNDSL &lip-1 &DecayAff lip-1 H_lip-1 &Txn1Aff NI K_NIlip-1 nu_NIlip-1 H_lip-1 &endlip-1 &LIP-1 &DecayAff LIP-1 H_LIP-1 &TlnAff lip-1 H_LIP-1 &endLIP-1 &dep_ACT &Formula1Aff dep_ACT &enddep_ACT &dep-1 &DecayAff dep-1 H_dep-1 &Txn2aAff MAPKP dep_ACT K_ACTdep nu_ACTdep H_dep-1 K_MAPKPdep-1 nu_MAPKPdep-1 &enddep-1 &DEP-1 &DecayAff DEP-1 H_DEP-1 &TlnAff dep-1 H_DEP-1 &endDEP-1 &ER &DecayAff ER H_ER &ConstantLevelAff H_ER Final_ER &ConversionEAff ER ERA r_ERera &EnzymeConversionEC_Pro_Aff ERA DEP-1 max_DEPera K_DEP-1 nu_DEP-1 &endER &ERA &DecayAff ERA H_ER &ConversionIAff ER ERA r_ERera &EndoEAff ERAI ERA endo_ERAI &EnzymeConversionEC_Sub_Aff ERA DEP-1 max_DEPera K_DEP-1 nu_DEP-1 &endERA &ERAI &DecayAff ERAI H_ERAI &EndoIAff ERAI ERA endo_ERAI &endERAI &MAPK &DecayAff MAPK H_MAPK &ConstantLevelAff H_MAPK Final_MAPK &EnzymeConversionEC_Pro_Aff MAPKP LIP-1 max_LIP-1mapk K_LIP-1 nu_LIP-1 &EnzymeConversionEC_Sub_Aff MAPK ERAI max_ERAImapk K_ERAI nu_ERAI &endMAPK &MAPKP &DecayAff MAPKP H_MAPK &EnzymeConversionEC_Sub_Aff MAPKP LIP-1 max_LIP-1mapk K_LIP-1 nu_LIP-1 &EnzymeConversionEC_Pro_Aff MAPK ERAI max_ERAImapk K_ERAI nu_ERAI &endMAPKP &endInteractions &ParameterValues &endo_ERAI 0.1 0.01 1 Logarithmic &endo_NI 0.1 0.01 1 Logarithmic &Final_ER 0.6 0 1 Linear &Final_MAPK 0.6 0.1 1 Linear &Final_N 0.6 0 1 Linear &H_dep-1 5 1 100 Linear &H_DEP-1 60 10 120 Logarithmic &H_dsl 5 1 100 Linear &H_DSL 60 10 120 Logarithmic &H_ER 60 10 120 Logarithmic &H_ERAI 60 10 120 Logarithmic &H_lip-1 5 1 100 Linear &H_LIP-1 60 10 120 Logarithmic &H_MAPK 60 10 120 Logarithmic &H_N 60 10 120 Logarithmic &H_N_min 1 1 40 Logarithmic &H_NDSL 60 10 120 Logarithmic &H_NI 60 10 120 Logarithmic &K_DEP-1 0.4 0.1 1 Logarithmic &K_ERAI 0.4 0.1 1 Logarithmic &K_LIP-1 0.4 0.1 1 Logarithmic &K_MAPKPdep-1 0.4 0.1 1 Logarithmic &K_MAPKPdsl 10 0.1 1 Logarithmic &K_NIlip-1 0.4 0.1 1 Logarithmic &K_MAPKPn 0.1 0.01 1 Logarithmic &max_DEPera 0.1 0.01 1 Logarithmic &max_LIP-1mapk 0.1 0.01 1 Logarithmic &max_ERAImapk 0.1 0.01 1 Logarithmic &nu_DEP-1 4 1 8 Linear &nu_ERAI 4 1 8 Linear &nu_LIP-1 4 1 8 Linear &nu_MAPKPdep-1 4 1 8 Linear &nu_MAPKPdsl 40 1 8 Linear &nu_NIlip-1 4 1 8 Linear &nu_MAPKPn 4 1 8 Linear &r_DSLN 1 0.01 1 Logarithmic &r_ERera 0.016 0.1 10 Logarithmic &maxN 1 0.1 10 Logarithmic &maxDSL 1 0.1 10 Logarithmic &K_ACTdep 0.1 0.01 1 Linear &nu_ACTdep 10 1 10 Logarithmic &ParameterRules &ProductBetweenRule &Param maxN &Param r_DSLN &LowerBound 0 &UpperBound 10 &endPR &ProductBetweenRule &Param maxDSL &Param r_DSLN &LowerBound 0 &UpperBound 10 &endPR &endParameterRules &endParameterValues &InitLevels &BackgroundLevel dsl 0 &BackgroundLevel DSL 0 &BackgroundLevel N 1 &BackgroundLevel NDSL 0 &BackgroundLevel NI 0 &BackgroundLevel lip-1 0 &BackgroundLevel LIP-1 0 &BackgroundLevel MAPK 1 &BackgroundLevel MAPKP 0 &BackgroundLevel dep-1 1 &BackgroundLevel DEP-1 1 &BackgroundLevel ER 1 &BackgroundLevel ERA 0 &BackgroundLevel ERAI 0 &BackgroundLevel dep_ACT 1 &endInitLevels &endNetwork