&Model

// The contents of this file are the work of G. von Dassow, E. Meir, E. M. Munro,
// and G. M. Odell, 1997-2000.  The model encoded in this file should be treated
// like any other piece of original scientific data, and must not be used in the
// production of any publication without the express permission of its creators.

&width		8
&height		2
&numsides	6
&extent		100

&Network	spnet

&Genes

	&en
		&Location	cyto
		&Color		cyan
		&Show		on
		&Scale		1
		&Type		rna
	&enden
	
	&EN
		&Location	cyto
		&Color		cyan
		&Show		off
		&Scale		1
		&Type		protein
	&endEN
	
	&wg
		&Location	cyto
		&Color		green
		&Show		on
		&Scale		1
		&Type		rna
	&endwg
	
	&IWG
		&Location	cyto
		&Color		green
		&Show		off
		&Scale		1
		&Type		protein
	&endIWG

	&EWG
		&Location	membrane
		&Color		green
		&Show		off
		&Scale		1
		&Type		protein
	&endEWG
	
	&ptc
		&Location	cyto
		&Color		magenta
		&Show		off
		&Scale		1
		&Type		rna
	&endptc
	
	&PTC
		&Location	membrane
		&Color		magenta
		&Show		off
		&Scale		1
		&Type		protein
	&endPTC
	
	&cid
		&Location	cyto
		&Color		pink
		&Show		off
		&Scale		1
		&Type		rna
	&endcid
	
	&CID	
		&Location	cyto
		&Color		pink
		&Show		on
		&Scale		1
		&Type		protein
	&endCID
	
	&CN
		&Location	cyto
		&Color		pink
		&Show		on
		&Scale		1
		&Type		protein
	&endCN
	
	&hh
		&Location	cyto
		&Color		red
		&Show		on
		&Scale		1
		&Type		rna
	&endhh
	
	&HH
		&Location	membrane
		&Color		red
		&Show		off
		&Scale		1
		&Type		protein
	&endHH
	
	&PH
		&Location	membrane
		&Color		magenta
		&Show		off
		&Scale		1
		&Type		complex
	&endPH
	
	&B
		&Location	cyto
		&Color		white
		&Show		off
		&Scale		1
		&Type		protein
	&endB
	
&endGenes

&Interactions
	&en
		&Txn2bAff CN EWG K_WGen nu_WGen H_en K_CNen nu_CNen
		&DecayAff en H_en
	&enden
	
	&EN
		&TlnAff en H_EN
		&DecayAff EN H_EN
	&endEN

	&wg
		&Txn4Aff CN IWG CID H_wg K_WGwg nu_WGwg alpha_wg K_CIDwg nu_CIDwg beta_wg K_CNwg nu_CNwg
		&DecayAff wg H_wg 
	&endwg
			
	&IWG
		&TlnAff wg H_IWG
		&EndoIAff IWG EWG Endo_WG
		&ExoIAff IWG EWG Exo_WG
		&DecayAff IWG H_IWG
	&endIWG

	&EWG
		&ExoEAff IWG EWG Exo_WG
		&EndoEAff IWG EWG Endo_WG
		&MxferOutAff EWG Mxfer_WG
		&MxferInAff EWG Mxfer_WG
		&LMxferEAff EWG LMxfer_WG
		&LMxferIAff EWG LMxfer_WG
		&DecayAff EWG H_EWG
	&endEWG

	&ptc
		&Txn2aAff CN CID K_CIDptc nu_CIDptc H_ptc K_CNptc nu_CNptc
		&DecayAff ptc H_ptc 
	&endptc

	&PTC
		&HeterodimerizeA_ECAff	PTC	HH	K_PTC_HH	maxHH
		&TlnAff ptc H_PTC 
		&LMxferEAff PTC LMxfer_PTC
		&LMxferIAff PTC LMxfer_PTC
		&DecayAff PTC H_PTC 
	&endPTC
			
	&cid
		&Txn2aAff EN B K_Bcid nu_Bcid H_cid K_ENcid nu_ENcid 
		&DecayAff cid H_cid 
	&endcid
			
	&CID
		&CleavageA_ICAff CID PTC K_PTCCID nu_PTCCID C_CID
		&TlnAff cid H_CID 
		&DecayAff CID H_CID 
	&endCID
			
	&CN
		&CleavageB_ICAff CID PTC K_PTCCID nu_PTCCID C_CID
		&DecayAff CN H_CN 
	&endCN
			
	&hh
		&Txn2aAff CN EN K_ENhh nu_ENhh H_hh K_CNhh nu_CNhh
		&DecayAff hh H_hh 
	&endhh
			
	&HH
		&HeterodimerizeA_ECAff	HH	PTC	K_PTC_HH	maxPTC
		&TlnAff hh H_HH 
		&LMxferEAff HH LMxfer_HH
		&LMxferIAff HH LMxfer_HH
		&DecayAff HH H_HH 
	&endHH
			
	&PH
		&HeterodimerizeB_ECAff	PTC	HH	K_PTC_HH	maxHH 
		&DecayAff PH H_PH 
	&endPH
			
	&B
		&Formula1Aff B
	&endB
&endInteractions

&ParameterValues

	&K_WGen	0.0030854277	0.0010	1.0	Logarithmic	
	&nu_WGen	9.259207	1.0	10.0	Linear	
	&H_en	79.02615	5.0	100.0	Linear	
	&K_CNen	0.020328883	0.0010	1.0	Logarithmic	
	&nu_CNen	4.8631816	1.0	10.0	Linear	
	&H_EN	82.15476	5.0	100.0	Linear	
	&H_wg	88.61211	5.0	100.0	Linear	
	&K_WGwg	0.21628724	0.0010	1.0	Logarithmic	
	&nu_WGwg	3.1461434	1.0	10.0	Linear	
	&alpha_wg	3.217238	1.0	10.0	Logarithmic	
	&K_CIDwg	0.04361901	0.0010	1.0	Logarithmic	
	&nu_CIDwg	3.418242	1.0	10.0	Linear	
	&beta_wg	2.0569775	1.0	10.0	Logarithmic	
	&K_CNwg	0.002130061	0.0010	1.0	Logarithmic	
	&nu_CNwg	7.58195	1.0	10.0	Linear	
	&H_IWG	51.24997	5.0	100.0	Linear	
	&Endo_WG	0.9351899	0.0010	1.0	Logarithmic	
	&Exo_WG	0.03804946	0.01	10.0	Logarithmic	
	&Mxfer_WG	0.006549734	0.0010	1.0	Logarithmic	
	&LMxfer_WG	0.1031645	0.0010	1.0	Logarithmic	
	&H_EWG	15.058761	5.0	100.0	Linear	
	&K_CIDptc	0.007021005	0.0010	1.0	Logarithmic	
	&nu_CIDptc	4.8034525	1.0	10.0	Linear	
	&H_ptc	51.082867	5.0	100.0	Linear	
	&K_CNptc	0.42212978	0.0010	1.0	Logarithmic	
	&nu_CNptc	9.199293	1.0	10.0	Linear	
	&K_PTC_HH	1.1138195E-5	1.0E-5	0.0010	Logarithmic	
	&maxHH	366138.22	1000.0	1000000.0	Logarithmic	
	&H_PTC	64.723076	5.0	100.0	Linear	
	&LMxfer_PTC	0.08869345	0.0010	1.0	Logarithmic	
	&K_Bcid	0.2675423	0.0010	1.0	Logarithmic	
	&nu_Bcid	1.0	1.0	1.0	Linear	
	&H_cid	49.941425	5.0	100.0	Linear	
	&K_ENcid	0.04256084	0.0010	1.0	Logarithmic	
	&nu_ENcid	4.1573334	1.0	10.0	Linear	
	&K_PTCCID	0.0018254414	0.0010	1.0	Logarithmic	
	&nu_PTCCID	3.2497425	1.0	10.0	Linear	
	&C_CID	0.5362515	0.0010	1.0	Logarithmic	
	&H_CID	6.025321	5.0	100.0	Linear	
	&H_CN	87.31108	5.0	100.0	Linear	
	&K_ENhh	0.0042555355	0.0010	1.0	Logarithmic	
	&nu_ENhh	7.871269	1.0	10.0	Linear	
	&H_hh	74.659096	5.0	100.0	Linear	
	&K_CNhh	0.009471223	0.0010	1.0	Logarithmic	
	&nu_CNhh	5.017085	1.0	10.0	Linear	
	&maxPTC	1064.8916	1000.0	1000000.0	Logarithmic	
	&H_HH	21.266705	5.0	100.0	Linear	
	&LMxfer_HH	0.0040825917	0.0010	1.0	Logarithmic	
	&H_PH	81.23694	5.0	100.0	Linear	

&endParameterValues

&InitLevels
	&BackgroundLevel	en		0.0
	&BackgroundLevel	EN		0.0
	&BackgroundLevel	wg 		0.0
	&BackgroundLevel	IWG		0.0
	&BackgroundLevel	EWG		0.0
	&BackgroundLevel	ptc		0.0
	&BackgroundLevel	PTC		0.0
	&BackgroundLevel	cid		0.0
	&BackgroundLevel	CID		0.0
	&BackgroundLevel	CN		0.0
	&BackgroundLevel	hh		0.0
	&BackgroundLevel	HH		0.0
	&BackgroundLevel	PH		0.0
	&BackgroundLevel	B		0.4
	&ColumnIC
		&Node	en
		&Value	1.0
		&Column	2
	&endIC
	&ColumnIC
		&Node	EN
		&Value	1.0
		&Column	2
	&endIC
	&ColumnIC
		&Node	wg
		&Value	1.0
		&Column	1
	&endIC
	&ColumnIC
		&Node	IWG
		&Value	1.0
		&Column	1
	&endIC
	&ColumnIC
		&Node	en
		&Value	1.0
		&Column	6
	&endIC
	&ColumnIC
		&Node	EN
		&Value	1.0
		&Column	6
	&endIC
	&ColumnIC
		&Node	wg
		&Value	1.0
		&Column	5
	&endIC
	&ColumnIC
		&Node	IWG
		&Value	1.0
		&Column	5
	&endIC
&endInitLevels

&endNetwork