&Model // The contents of this file are the work of G. von Dassow, E. Meir, E. M. Munro, // and G. M. Odell, 1997-2000. The model encoded in this file should be treated // like any other piece of original scientific data, and must not be used in the // production of any publication without the express permission of its creators. &width 8 &height 2 &numsides 6 &extent 100 &Network spnet &Genes &en &Location cyto &Color cyan &Show on &Scale 1 &Type rna &enden &EN &Location cyto &Color cyan &Show off &Scale 1 &Type protein &endEN &wg &Location cyto &Color green &Show on &Scale 1 &Type rna &endwg &IWG &Location cyto &Color green &Show off &Scale 1 &Type protein &endIWG &EWG &Location membrane &Color green &Show off &Scale 1 &Type protein &endEWG &ptc &Location cyto &Color magenta &Show off &Scale 1 &Type rna &endptc &PTC &Location membrane &Color magenta &Show off &Scale 1 &Type protein &endPTC &cid &Location cyto &Color pink &Show off &Scale 1 &Type rna &endcid &CID &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCID &CN &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCN &hh &Location cyto &Color red &Show on &Scale 1 &Type rna &endhh &HH &Location membrane &Color red &Show off &Scale 1 &Type protein &endHH &PH &Location membrane &Color magenta &Show off &Scale 1 &Type complex &endPH &B &Location cyto &Color white &Show off &Scale 1 &Type protein &endB &endGenes &Interactions &en &Txn2bAff CN EWG K_WGen nu_WGen H_en K_CNen nu_CNen &DecayAff en H_en &enden &EN &TlnAff en H_EN &DecayAff EN H_EN &endEN &wg &Txn4Aff CN IWG CID H_wg K_WGwg nu_WGwg alpha_wg K_CIDwg nu_CIDwg beta_wg K_CNwg nu_CNwg &DecayAff wg H_wg &endwg &IWG &TlnAff wg H_IWG &EndoIAff IWG EWG Endo_WG &ExoIAff IWG EWG Exo_WG &DecayAff IWG H_IWG &endIWG &EWG &ExoEAff IWG EWG Exo_WG &EndoEAff IWG EWG Endo_WG &MxferOutAff EWG Mxfer_WG &MxferInAff EWG Mxfer_WG &LMxferEAff EWG LMxfer_WG &LMxferIAff EWG LMxfer_WG &DecayAff EWG H_EWG &endEWG &ptc &Txn2aAff CN CID K_CIDptc nu_CIDptc H_ptc K_CNptc nu_CNptc &DecayAff ptc H_ptc &endptc &PTC &HeterodimerizeA_ECAff PTC HH K_PTC_HH maxHH &TlnAff ptc H_PTC &LMxferEAff PTC LMxfer_PTC &LMxferIAff PTC LMxfer_PTC &DecayAff PTC H_PTC &endPTC &cid &Txn2aAff EN B K_Bcid nu_Bcid H_cid K_ENcid nu_ENcid &DecayAff cid H_cid &endcid &CID &CleavageA_ICAff CID PTC K_PTCCID nu_PTCCID C_CID &TlnAff cid H_CID &DecayAff CID H_CID &endCID &CN &CleavageB_ICAff CID PTC K_PTCCID nu_PTCCID C_CID &DecayAff CN H_CN &endCN &hh &Txn2aAff CN EN K_ENhh nu_ENhh H_hh K_CNhh nu_CNhh &DecayAff hh H_hh &endhh &HH &HeterodimerizeA_ECAff HH PTC K_PTC_HH maxPTC &TlnAff hh H_HH &LMxferEAff HH LMxfer_HH &LMxferIAff HH LMxfer_HH &DecayAff HH H_HH &endHH &PH &HeterodimerizeB_ECAff PTC HH K_PTC_HH maxHH &DecayAff PH H_PH &endPH &B &Formula1Aff B &endB &endInteractions &ParameterValues &K_WGen 0.07783293 0.0010 1.0 Logarithmic &nu_WGen 7.5869107 1.0 10.0 Linear &H_en 19.95295 5.0 100.0 Linear &K_CNen 0.0012503975 0.0010 1.0 Logarithmic &nu_CNen 4.335797 1.0 10.0 Linear &H_EN 40.67838 5.0 100.0 Linear &H_wg 63.33802 5.0 100.0 Linear &K_WGwg 0.0038505571 0.0010 1.0 Logarithmic &nu_WGwg 9.795079 1.0 10.0 Linear &alpha_wg 7.514226 1.0 10.0 Logarithmic &K_CIDwg 0.32583192 0.0010 1.0 Logarithmic &nu_CIDwg 8.162406 1.0 10.0 Linear &beta_wg 4.509463 1.0 10.0 Logarithmic &K_CNwg 0.018420588 0.0010 1.0 Logarithmic &nu_CNwg 6.3564754 1.0 10.0 Linear &H_IWG 11.772343 5.0 100.0 Linear &Endo_WG 0.003170321 0.0010 1.0 Logarithmic &Exo_WG 0.013362445 0.01 10.0 Logarithmic &Mxfer_WG 0.002212903 0.0010 1.0 Logarithmic &LMxfer_WG 0.00840172 0.0010 1.0 Logarithmic &H_EWG 98.10517 5.0 100.0 Linear &K_CIDptc 0.00260831 0.0010 1.0 Logarithmic &nu_CIDptc 9.1684 1.0 10.0 Linear &H_ptc 87.442314 5.0 100.0 Linear &K_CNptc 0.013272183 0.0010 1.0 Logarithmic &nu_CNptc 6.3843307 1.0 10.0 Linear &K_PTC_HH 3.0935564000000004E-5 1.0E-5 0.0010 Logarithmic &maxHH 18719.434 1000.0 1000000.0 Logarithmic &H_PTC 5.219935 5.0 100.0 Linear &LMxfer_PTC 0.17924207 0.0010 1.0 Logarithmic &K_Bcid 0.46078876 0.0010 1.0 Logarithmic &nu_Bcid 1.0 1.0 1.0 Linear &H_cid 46.325226 5.0 100.0 Linear &K_ENcid 0.014838101 0.0010 1.0 Logarithmic &nu_ENcid 4.4364123 1.0 10.0 Linear &K_PTCCID 0.0012393896 0.0010 1.0 Logarithmic &nu_PTCCID 6.816081 1.0 10.0 Linear &C_CID 0.01465381 0.0010 1.0 Logarithmic &H_CID 22.938326 5.0 100.0 Linear &H_CN 9.621367 5.0 100.0 Linear &K_ENhh 0.02762508 0.0010 1.0 Logarithmic &nu_ENhh 9.38592 1.0 10.0 Linear &H_hh 96.60705 5.0 100.0 Linear &K_CNhh 0.3729521 0.0010 1.0 Logarithmic &nu_CNhh 4.6340733 1.0 10.0 Linear &maxPTC 275975.8 1000.0 1000000.0 Logarithmic &H_HH 40.70792 5.0 100.0 Linear &LMxfer_HH 0.510931 0.0010 1.0 Logarithmic &H_PH 74.78441 5.0 100.0 Linear &endParameterValues &InitLevels &BackgroundLevel en 0.0 &BackgroundLevel EN 0.0 &BackgroundLevel wg 0.0 &BackgroundLevel IWG 0.0 &BackgroundLevel EWG 0.0 &BackgroundLevel ptc 0.0 &BackgroundLevel PTC 0.0 &BackgroundLevel cid 0.0 &BackgroundLevel CID 0.0 &BackgroundLevel CN 0.0 &BackgroundLevel hh 0.0 &BackgroundLevel HH 0.0 &BackgroundLevel PH 0.0 &BackgroundLevel B 0.4 &ColumnIC &Node en &Value 1.0 &Column 2 &endIC &ColumnIC &Node EN &Value 1.0 &Column 2 &endIC &ColumnIC &Node wg &Value 1.0 &Column 1 &endIC &ColumnIC &Node IWG &Value 1.0 &Column 1 &endIC &ColumnIC &Node en &Value 1.0 &Column 6 &endIC &ColumnIC &Node EN &Value 1.0 &Column 6 &endIC &ColumnIC &Node wg &Value 1.0 &Column 5 &endIC &ColumnIC &Node IWG &Value 1.0 &Column 5 &endIC &endInitLevels &endNetwork