&Model // The contents of this file are the work of G. von Dassow, E. Meir, E. M. Munro, // and G. M. Odell, 1997-2000. The model encoded in this file should be treated // like any other piece of original scientific data, and must not be used in the // production of any publication without the express permission of its creators. &width 4 &height 1 &numsides 6 &extent 100 &Network spnet &Genes &en &Location cyto &Color cyan &Show on &Scale 1 &Type rna &enden &EN &Location cyto &Color cyan &Show on &Scale 1 &Type protein &endEN &wg &Location cyto &Color green &Show on &Scale 1 &Type rna &endwg &IWG &Location cyto &Color green &Show on &Scale 1 &Type protein &endIWG &EWG &Location membrane &Color green &Show on &Scale 1 &Type protein &endEWG &ptc &Location cyto &Color magenta &Show on &Scale 1 &Type rna &endptc &PTC &Location membrane &Color magenta &Show on &Scale 1 &Type protein &endPTC &cid &Location cyto &Color pink &Show on &Scale 1 &Type rna &endcid &CID &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCID &CN &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCN &hh &Location cyto &Color red &Show on &Scale 1 &Type rna &endhh &HH &Location membrane &Color red &Show on &Scale 1 &Type protein &endHH &PH &Location membrane &Color magenta &Show on &Scale 1 &Type complex &endPH &B &Location cyto &Color white &Show off &Scale 1 &Type protein &endB &endGenes &Interactions &en &Txn2bPerAff CN EWG K_WGen nu_WGen H_en K_CNen nu_CNen &DecayAff en H_en &enden &EN &TlnAff en H_EN &DecayAff EN H_EN &endEN &wg &Txn4PerAff CN IWG CID H_wg K_WGwg nu_WGwg alpha_wg K_CIDwg nu_CIDwg beta_wg K_CNwg nu_CNwg &DecayAff wg H_wg &endwg &IWG &TlnAff wg H_IWG &EndoIAff IWG EWG Endo_WG &ExoIAff IWG EWG Exo_WG &DecayAff IWG H_IWG &endIWG &EWG &ExoEAff IWG EWG Exo_WG &EndoEAff IWG EWG Endo_WG &MxferOutAff EWG Mxfer_WG &MxferInAff EWG Mxfer_WG &LMxferEAff EWG LMxfer_WG &LMxferIAff EWG LMxfer_WG &DecayAff EWG H_EWG &endEWG &ptc &Txn2aPerAff CN CID K_CIDptc nu_CIDptc H_ptc K_CNptc nu_CNptc &DecayAff ptc H_ptc &endptc &PTC &HeterodimerizeA_ECAff PTC HH K_PTC_HH maxHH &TlnAff ptc H_PTC &LMxferEAff PTC LMxfer_PTC &LMxferIAff PTC LMxfer_PTC &DecayAff PTC H_PTC &endPTC &cid &Txn2aPerAff EN B K_Bcid nu_Bcid H_cid K_ENcid nu_ENcid &DecayAff cid H_cid &endcid &CID &CleavageA_ICAff CID PTC K_PTCCID nu_PTCCID C_CID &TlnAff cid H_CID &DecayAff CID H_CID &endCID &CN &CleavageB_ICAff CID PTC K_PTCCID nu_PTCCID C_CID &DecayAff CN H_CN &endCN &hh &Txn2aPerAff CN EN K_ENhh nu_ENhh H_hh K_CNhh nu_CNhh &DecayAff hh H_hh &endhh &HH &HeterodimerizeA_ECAff HH PTC K_PTC_HH maxPTC &TlnAff hh H_HH &LMxferEAff HH LMxfer_HH &LMxferIAff HH LMxfer_HH &DecayAff HH H_HH &endHH &PH &HeterodimerizeB_ECAff PTC HH K_PTC_HH maxHH &DecayAff PH H_PH &endPH &B &Formula1Aff B &endB &endInteractions &ParameterValues &K_WGen 0.1 0.001 1.0 Logarithmic &K_CNen 0.1 0.001 1.0 Logarithmic &K_WGwg 0.1 0.001 1.0 Logarithmic &K_CIDwg 0.1 0.001 1.0 Logarithmic &K_CNwg 0.1 0.001 1.0 Logarithmic &K_CIDptc 0.1 0.001 1.0 Logarithmic &K_CNptc 0.1 0.001 1.0 Logarithmic &K_Bcid 0.1 0.001 1.0 Logarithmic &K_ENcid 0.1 0.001 1.0 Logarithmic &K_PTCCID 0.1 0.001 1.0 Logarithmic &K_ENhh 0.1 0.001 1.0 Logarithmic &K_CNhh 0.1 0.001 1.0 Logarithmic &K_PTC_HH 0.0001 0.00001 0.001 Logarithmic &maxPTC 1000 1000 1000000 Logarithmic &maxHH 1000 1000 1000000 Logarithmic &C_CID 0.1 0.01 1.0 Logarithmic &nu_WGen 1.0 1.0 10.0 Linear &nu_CNen 1.0 1.0 10.0 Linear &nu_WGwg 1.0 1.0 10.0 Linear &nu_CIDwg 1.0 1.0 10.0 Linear &nu_CNwg 1.0 1.0 10.0 Linear &nu_CIDptc 1.0 1.0 10.0 Linear &nu_CNptc 1.0 1.0 10.0 Linear &nu_Bcid 1.0 1.0 1.0 Linear &nu_ENcid 1.0 1.0 10.0 Linear &nu_PTCCID 1.0 1.0 10.0 Linear &nu_ENhh 1.0 1.0 10.0 Linear &nu_CNhh 1.0 1.0 10.0 Linear &H_en 7.0 5.0 100.0 Linear &H_EN 15.0 5.0 100.0 Linear &H_wg 7.0 5.0 100.0 Linear &H_IWG 15.0 5.0 100.0 Linear &H_EWG 15.0 5.0 100.0 Linear &H_ptc 7.0 5.0 100.0 Linear &H_PTC 15.0 5.0 100.0 Linear &H_cid 7.0 5.0 100.0 Linear &H_CID 15.0 5.0 100.0 Linear &H_CN 15.0 5.0 100.0 Linear &H_hh 7.0 5.0 100.0 Linear &H_HH 15.0 5.0 100.0 Linear &H_PH 15.0 5.0 100.0 Linear &alpha_wg 1.0 1.0 10.0 Logarithmic &beta_wg 1.0 1.0 10.0 Logarithmic &Endo_WG 0.001 0.001 1.0 Logarithmic &Exo_WG 0.1 0.01 10.0 Logarithmic &Mxfer_WG 0.001 0.001 1.0 Logarithmic &LMxfer_WG 0.1 0.001 1.0 Logarithmic &LMxfer_PTC 0.1 0.001 1.0 Logarithmic &LMxfer_HH 0.1 0.001 1.0 Logarithmic &endParameterValues &InitLevels &BackgroundLevel en 0.0 &BackgroundLevel EN 0.0 &BackgroundLevel wg 0.0 &BackgroundLevel IWG 0.0 &BackgroundLevel EWG 0.0 &BackgroundLevel ptc 0.0 &BackgroundLevel PTC 0.0 &BackgroundLevel cid 0.0 &BackgroundLevel CID 0.0 &BackgroundLevel CN 0.0 &BackgroundLevel hh 0.0 &BackgroundLevel HH 0.0 &BackgroundLevel PH 0.0 &BackgroundLevel B 0.4 &ColumnIC &Node en &Value 1.0 &Column 2 &endIC &ColumnIC &Node EN &Value 1.0 &Column 2 &endIC &ColumnIC &Node wg &Value 1.0 &Column 1 &endIC &ColumnIC &Node IWG &Value 1.0 &Column 1 &endIC &endInitLevels &endNetwork