&Model // The contents of this file are the work of G. von Dassow, E. Meir, E. M. Munro, // and G. M. Odell, 1997-2000. The model encoded in this file should be treated // like any other piece of original scientific data, and must not be used in the // production of any publication without the express permission of its creators. // Diploidized by Kerry Kim (by hand, working on automation) 4/4/6 // Assuming that total individual alleles work independently (no competition, // and the individual activities sum after passing through nonlinearity). // Not realistic, but a 1st approximation // See spg1_4celldiploid2.net for a slightly improved version calling different // diploidizing affectors &width 4 &height 1 &numsides 6 &extent 100 &Network spg1_4celldiploid &Genes &en1 &Location cyto &Color cyan &Show on &Scale 1 &Type rna &enden1 &en2 &Location cyto &Color cyan &Show on &Scale 1 &Type rna &enden2 &EN1 &Location cyto &Color cyan &Show on &Scale 1 &Type protein &endEN1 &EN2 &Location cyto &Color cyan &Show on &Scale 1 &Type protein &endEN2 &wg1 &Location cyto &Color green &Show on &Scale 1 &Type rna &endwg1 &wg2 &Location cyto &Color green &Show on &Scale 1 &Type rna &endwg2 &IWG1 &Location cyto &Color green &Show off &Scale 1 &Type protein &endIWG1 &IWG2 &Location cyto &Color green &Show off &Scale 1 &Type protein &endIWG2 &EWG1 &Location membrane &Color green &Show off &Scale 1 &Type protein &endEWG1 &EWG2 &Location membrane &Color green &Show off &Scale 1 &Type protein &endEWG2 &ptc1 &Location cyto &Color magenta &Show off &Scale 1 &Type rna &endptc1 &ptc2 &Location cyto &Color magenta &Show off &Scale 1 &Type rna &endptc2 &PTC1 &Location membrane &Color magenta &Show off &Scale 1 &Type protein &endPTC1 &PTC2 &Location membrane &Color magenta &Show off &Scale 1 &Type protein &endPTC2 &cid1 &Location cyto &Color pink &Show off &Scale 1 &Type rna &endcid1 &cid2 &Location cyto &Color pink &Show off &Scale 1 &Type rna &endcid2 &CID1 &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCID1 &CID2 &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCID2 &CN1 &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCN1 &CN2 &Location cyto &Color pink &Show on &Scale 1 &Type protein &endCN2 &hh1 &Location cyto &Color red &Show on &Scale 1 &Type rna &endhh1 &hh2 &Location cyto &Color red &Show on &Scale 1 &Type rna &endhh2 &HH1 &Location membrane &Color red &Show off &Scale 1 &Type protein &endHH1 &HH2 &Location membrane &Color red &Show off &Scale 1 &Type protein &endHH2 &PH1 &Location membrane &Color magenta &Show off &Scale 1 &Type complex &endPH1 &PH2 &Location membrane &Color magenta &Show off &Scale 1 &Type complex &endPH2 &B &Location cyto &Color white &Show off &Scale 1 &Type protein &endB &endGenes &Interactions &en1 &Txn2bDipAff CN1 CN2 EWG1 EWG2 K_WG1en1 KWG2en1 nu_WG1en1 nu_WG2en1 H_en1 K_CN1en1 K_CN1en2 K_CN2en1 K_CN2en2 nu_CN1en1 nu_CN1en2 nu_CN2en1 nu_CN2en2 &DecayAff en1 H_en1 &enden &en2 &Txn2bDipAff CN1 CN2 EWG1 EWG2 K_WG1en2 KWG2en2 nu_WG1en2 nu_WG2en2 H_en2 K_CN1en1 K_CN1en2 K_CN2en1 K_CN2en2 nu_CN1en1 nu_CN1en2 nu_CN2en1 nu_CN2en2 &DecayAff en1 H_en1 &enden2 &EN1 &TlnAff en1 H_EN1 &DecayAff EN1 H_EN1 &endEN1 &EN2 &TlnAff en2 H_EN2 &DecayAff EN2 H_EN2 &endEN2 &wg1 &Txn4DipAff CN1 CN2 IWG1 IWG2 CID1 CID2 H_wg1 K_WG1wg1 K_WG2wg1 nu_WG1wg1 nu_WG2wg1 alpha_wg11 alpha_wg12 K_CID1wg1 K_CID2wg1 nu_CID1wg1 nu_CID2wg1 beta_wg11 beta_wg12 K_CN1wg1 K_CN1wg2 K_CN2wg2 K_CN2wg2 nu_CN1wg1 nu_CN1wg2 nu_CN2wg1 nu_CN2wg2 &DecayAff wg1 H_wg1 &endwg1 &wg2 &Txn4DipAff CN1 CN2 IWG1 IWG2 CID1 CID2 H_wg2 K_WG1wg2 K_WG2wg2 nu_WG1wg2 nu_WG2wg2 alpha_wg21 alpha_wg22 K_CID1wg2 K_CID2wg2 nu_CID1wg2 nu_CID2wg2 beta_wg21 beta_wg22 K_CN1wg1 K_CN1wg2 K_CN2wg2 K_CN2wg2 nu_CN1wg1 nu_CN1wg2 nu_CN2wg1 nu_CN2wg2 &DecayAff wg2 H_wg2 &endwg2 &IWG1 &TlnAff wg1 H_IWG1 &EndoIAff IWG1 EWG1 Endo_WG1 &ExoIAff IWG1 EWG1 Exo_WG1 &DecayAff IWG1 H_IWG1 &endIWG1 &IWG2 &TlnAff wg2 H_IWG2 &EndoIAff IWG2 EWG2 Endo_WG2 &ExoIAff IWG2 EWG2 Exo_WG2 &DecayAff IWG2 H_IWG2 &endIWG2 &EWG1 &ExoEAff IWG1 EWG1 Exo_WG1 &EndoEAff IWG1 EWG1 Endo_WG1 &MxferOutAff EWG1 Mxfer_WG1 &MxferInAff EWG1 Mxfer_WG1 &LMxferEAff EWG1 LMxfer_WG1 &LMxferIAff EWG1 LMxfer_WG1 &DecayAff EWG1 H_EWG1 &endEWG1 &EWG2 &ExoEAff IWG2 EWG2 Exo_WG2 &EndoEAff IWG EWG2 Endo_WG2 &MxferOutAff EWG2 Mxfer_WG2 &MxferInAff EWG2 Mxfer_WG2 &LMxferEAff EWG2 LMxfer_WG2 &LMxferIAff EWG2 LMxfer_WG2 &DecayAff EWG2 H_EWG2 &endEWG2 &ptc1 &Txn2aDipAff CN1 CN2 CID1 CID2 K_CID1ptc1 K_CID2ptc1 nu_CID1ptc1 nu_CID2ptc1 H_ptc1 K_CN1ptc1 K_CN1ptc2 K_CN2ptc1 K_CN2ptc2 nu_CN1ptc1 nu_CN1ptc2 nu_CN2ptc1 nu_CN2ptc2 &DecayAff ptc1 H_ptc1 &endptc1 &ptc2 &Txn2aDipAff CN1 CN2 CID1 CID2 K_CID1ptc2 K_CID2ptc2 nu_CID1ptc2 nu_CID2ptc2 H_ptc2 K_CN1ptc1 K_CN1ptc2 K_CN2ptc1 K_CN2ptc2 nu_CN1ptc1 nu_CN1ptc2 nu_CN2ptc1 nu_CN2ptc2 &DecayAff ptc2 H_ptc2 &endptc2 &PTC1 &HeterodimerizeA_ECAff PTC1 HH1 K_PTC1_HH1 maxHH1 &HeterodimerizeA_ECAff PTC1 HH2 K_PTC1_HH2 maxHH2 &TlnAff ptc1 H_PTC1 &LMxferEAff PTC1 LMxfer_PTC1 &LMxferIAff PTC1 LMxfer_PTC1 &DecayAff PTC1 H_PTC1 &endPTC1 &PTC2 &HeterodimerizeA_ECAff PTC2 HH1 K_PTC2_HH1 maxHH1 &HeterodimerizeA_ECAff PTC2 HH2 K_PTC2_HH2 maxHH2 &TlnAff ptc2 H_PTC2 &LMxferEAff PTC2 LMxfer_PTC2 &LMxferIAff PTC2 LMxfer_PTC2 &DecayAff PTC2 H_PTC2 &endPTC2 &cid1 &Txn2aDipAff EN1 EN2 B B K_Bcid1 K_Bcid1 nu_Bcid1 nu_Bcid1 H_cid1 K_EN1cid1 K_EN1cid2 K_EN2cid1 K_EN2cid2 nu_EN1cid1 nu_EN1cid2 nu_EN2cid1 nu_EN2cid2 &DecayAff cid1 H_cid1 &endcid1 &cid2 &Txn2aDipAff EN1 EN2 B B K_Bcid2 K_Bcid2 nu_Bcid2 nu_Bcid2 H_cid2 K_EN1cid1 K_EN1cid2 K_EN2cid1 K_EN2cid2 nu_EN1cid1 nu_EN1cid2 nu_EN2cid1 nu_EN2cid2 &DecayAff cid1 H_cid1 &endcid2 &CID1 &CleavageA_ICDipAff CID1 PTC1 PTC2 K_PTC1CID1 K_PTC2CID1 nu_PTC1CID1 nu_PTC2CID1 C_PTC1CID1 C_PTC2CID1 &TlnAff cid1 H_CID1 &DecayAff CID1 H_CID1 &endCID1 &CID2 &CleavageA_ICDipAff CID2 PTC1 PTC2 K_PTC1CID2 K_PTC2CID2 nu_PTC1CID2 nu_PTC2CID2 C_PTC1CID2 C_PTC2CID2 &TlnAff cid2 H_CID2 &DecayAff CID2 H_CID2 &endCID2 &CN1 &CleavageB_ICDipAff CID1 PTC1 PTC2 K_PTC1CID1 K_PTC2CID1 nu_PTC1CID1 nu_PTC2CID1 C_PTC1CID1 C_PTC2CID1 &DecayAff CN1 H_CN1 &endCN1 &CN2 &CleavageB_ICDipAff CID2 PTC1 PTC2 K_PTC1CID2 K_PTC2CID2 nu_PTC1CID2 nu_PTC2CID2 C_PTC1CID2 C_PTC2CID2 &DecayAff CN2 H_CN2 &endCN2 &hh1 &Txn2aDipAff CN1 CN2 EN1 EN2 K_EN1hh1 K_EN2hh1 nu_EN1hh1 nu_EN2hh1 H_hh1 K_CN1hh1 K_CN1hh2 K_CN2hh1 K_CN2hh2 nu_CN1hh1 nu_CN1hh2 nu_CN2hh1 nu_CN2hh2 &DecayAff hh1 H_hh1 &endhh1 &hh2 &Txn2aDipAff CN1 CN2 EN1 EN2 K_EN1hh2 K_EN2hh2 nu_EN1hh2 nu_EN2hh2 H_hh2 K_CN1hh1 K_CN1hh2 K_CN2hh1 K_CN2hh2 nu_CN1hh1 nu_CN1hh2 nu_CN2hh1 nu_CN2hh2 &DecayAff hh2 H_hh2 &endhh2 &HH1 &HeterodimerizeA_ECAff PTC1 HH1 K_PTC1_HH1 maxPTC1 &HeterodimerizeA_ECAff PTC2 HH1 K_PTC2_HH1 maxPTC2 &TlnAff hh1 H_HH1 &LMxferEAff HH1 LMxfer_HH1 &LMxferIAff HH1 LMxfer_HH1 &DecayAff HH1 H_HH1 &endHH1 &HH2 &HeterodimerizeA_ECAff PTC1 HH2 K_PTC1_HH2 maxPTC1 &HeterodimerizeA_ECAff PTC2 HH2 K_PTC2_HH2 maxPTC2 &TlnAff hh2 H_HH2 &LMxferEAff HH2 LMxfer_HH2 &LMxferIAff HH2 LMxfer_HH2 &DecayAff HH2 H_HH2 &endHH2 &PH11 &HeterodimerizeB_ECAff PTC1 HH1 K_PTC1_HH1 maxHH1 &DecayAff PH11 H_PH11 &endPH11 &PH12 &HeterodimerizeB_ECAff PTC1 HH2 K_PTC1_HH2 maxHH2 &DecayAff PH12 H_PH12 &endPH12 &PH21 &HeterodimerizeB_ECAff PTC2 HH1 K_PTC2_HH1 maxHH1 &DecayAff PH21 H_PH21 &endPH21 &PH22 &HeterodimerizeB_ECAff PTC2 HH2 K_PTC2_HH2 maxHH2 &DecayAff PH22 H_PH22 &endPH22 &B &Formula1Aff B &endB &endInteractions &ParameterValues &K_WG1en1 0.1 0.001 1.0 Logarithmic &K_WG1en2 0.1 0.001 1.0 Logarithmic &K_WG2en1 0.1 0.001 1.0 Logarithmic &K_WG2en2 0.1 0.001 1.0 Logarithmic &K_CN1en1 0.1 0.001 1.0 Logarithmic &K_CN1en2 0.1 0.001 1.0 Logarithmic &K_CN2en1 0.1 0.001 1.0 Logarithmic &K_CN2en2 0.1 0.001 1.0 Logarithmic &K_WG1wg1 0.1 0.001 1.0 Logarithmic &K_WG1wg2 0.1 0.001 1.0 Logarithmic &K_WG2wg1 0.1 0.001 1.0 Logarithmic &K_WG2wg2 0.1 0.001 1.0 Logarithmic &K_CID1wg1 0.1 0.001 1.0 Logarithmic &K_CID1wg2 0.1 0.001 1.0 Logarithmic &K_CID2wg1 0.1 0.001 1.0 Logarithmic &K_CID2wg2 0.1 0.001 1.0 Logarithmic &K_CN1wg1 0.1 0.001 1.0 Logarithmic &K_CN1wg2 0.1 0.001 1.0 Logarithmic &K_CN2wg1 0.1 0.001 1.0 Logarithmic &K_CN2wg2 0.1 0.001 1.0 Logarithmic &K_CID1ptc1 0.1 0.001 1.0 Logarithmic &K_CID1ptc2 0.1 0.001 1.0 Logarithmic &K_CID2ptc1 0.1 0.001 1.0 Logarithmic &K_CID2ptc2 0.1 0.001 1.0 Logarithmic &K_CN1ptc1 0.1 0.001 1.0 Logarithmic &K_CN2ptc1 0.1 0.001 1.0 Logarithmic &K_CN2ptc2 0.1 0.001 1.0 Logarithmic &K_CN2ptc2 0.1 0.001 1.0 Logarithmic &K_Bcid1 0.1 0.001 1.0 Logarithmic &K_Bcid2 0.1 0.001 1.0 Logarithmic &K_EN1cid1 0.1 0.001 1.0 Logarithmic &K_EN1cid2 0.1 0.001 1.0 Logarithmic &K_EN2cid1 0.1 0.001 1.0 Logarithmic &K_EN2cid2 0.1 0.001 1.0 Logarithmic &K_PTC1CID1 0.1 0.001 1.0 Logarithmic &K_PTC1CID2 0.1 0.001 1.0 Logarithmic &K_PTC2CID1 0.1 0.001 1.0 Logarithmic &K_PTC2CID2 0.1 0.001 1.0 Logarithmic &K_EN1hh1 0.1 0.001 1.0 Logarithmic &K_EN1hh2 0.1 0.001 1.0 Logarithmic &K_EN2hh1 0.1 0.001 1.0 Logarithmic &K_EN2hh2 0.1 0.001 1.0 Logarithmic &K_CN1hh1 0.1 0.001 1.0 Logarithmic &K_CN1hh2 0.1 0.001 1.0 Logarithmic &K_CN2hh1 0.1 0.001 1.0 Logarithmic &K_CN2hh2 0.1 0.001 1.0 Logarithmic &K_PTC1_HH1 0.0001 0.00001 0.001 Logarithmic &K_PTC1_HH2 0.0001 0.00001 0.001 Logarithmic &K_PTC2_HH1 0.0001 0.00001 0.001 Logarithmic &K_PTC2_HH2 0.0001 0.00001 0.001 Logarithmic &maxPTC1 1000 1000 1000000 Logarithmic &maxPTC2 1000 1000 1000000 Logarithmic &maxHH1 1000 1000 1000000 Logarithmic &maxHH2 1000 1000 1000000 Logarithmic &C_PTC1CID1 0.1 0.01 1.0 Logarithmic &C_PTC1CID2 0.1 0.01 1.0 Logarithmic &C_PTC2CID1 0.1 0.01 1.0 Logarithmic &C_PTC2CID2 0.1 0.01 1.0 Logarithmic &nu_WG1en1 1.0 1.0 10.0 Linear &nu_WG1en2 1.0 1.0 10.0 Linear &nu_WG2en1 1.0 1.0 10.0 Linear &nu_WG2en2 1.0 1.0 10.0 Linear &nu_CN1en1 1.0 1.0 10.0 Linear &nu_CN1en2 1.0 1.0 10.0 Linear &nu_CN2en1 1.0 1.0 10.0 Linear &nu_CN2en2 1.0 1.0 10.0 Linear &nu_WG1wg1 1.0 1.0 10.0 Linear &nu_WG1wg2 1.0 1.0 10.0 Linear &nu_WG2wg1 1.0 1.0 10.0 Linear &nu_WG2wg2 1.0 1.0 10.0 Linear &nu_CID1wg1 1.0 1.0 10.0 Linear &nu_CID1wg2 1.0 1.0 10.0 Linear &nu_CID2wg1 1.0 1.0 10.0 Linear &nu_CID2wg2 1.0 1.0 10.0 Linear &nu_CN1wg1 1.0 1.0 10.0 Linear &nu_CN1wg2 1.0 1.0 10.0 Linear &nu_CN2wg1 1.0 1.0 10.0 Linear &nu_CN2wg2 1.0 1.0 10.0 Linear &nu_CID1ptc1 1.0 1.0 10.0 Linear &nu_CID1ptc2 1.0 1.0 10.0 Linear &nu_CID2ptc1 1.0 1.0 10.0 Linear &nu_CID2ptc2 1.0 1.0 10.0 Linear &nu_CN1ptc1 1.0 1.0 10.0 Linear &nu_CN1ptc2 1.0 1.0 10.0 Linear &nu_CN2ptc1 1.0 1.0 10.0 Linear &nu_CN2ptc2 1.0 1.0 10.0 Linear &nu_Bcid1 1.0 1.0 1.0 Linear &nu_Bcid2 1.0 1.0 1.0 Linear &nu_EN1cid1 1.0 1.0 10.0 Linear &nu_EN1cid2 1.0 1.0 10.0 Linear &nu_EN2cid1 1.0 1.0 10.0 Linear &nu_EN2cid2 1.0 1.0 10.0 Linear &nu_PTC1CID1 1.0 1.0 10.0 Linear &nu_PTC1CID2 1.0 1.0 10.0 Linear &nu_PTC2CID1 1.0 1.0 10.0 Linear &nu_PTC2CID2 1.0 1.0 10.0 Linear &nu_EN1hh1 1.0 1.0 10.0 Linear &nu_EN1hh2 1.0 1.0 10.0 Linear &nu_EN2hh1 1.0 1.0 10.0 Linear &nu_EN2hh2 1.0 1.0 10.0 Linear &nu_CN1hh1 1.0 1.0 10.0 Linear &nu_CN1hh2 1.0 1.0 10.0 Linear &nu_CN2hh1 1.0 1.0 10.0 Linear &nu_CN2hh2 1.0 1.0 10.0 Linear &H_en1 7.0 5.0 100.0 Linear &H_en2 7.0 5.0 100.0 Linear &H_EN1 15.0 5.0 100.0 Linear &H_EN2 15.0 5.0 100.0 Linear &H_wg1 7.0 5.0 100.0 Linear &H_wg2 7.0 5.0 100.0 Linear &H_IWG1 15.0 5.0 100.0 Linear &H_IWG2 15.0 5.0 100.0 Linear &H_EWG1 15.0 5.0 100.0 Linear &H_EWG2 15.0 5.0 100.0 Linear &H_ptc1 7.0 5.0 100.0 Linear &H_ptc2 7.0 5.0 100.0 Linear &H_PTC1 15.0 5.0 100.0 Linear &H_PTC2 15.0 5.0 100.0 Linear &H_cid1 7.0 5.0 100.0 Linear &H_cid2 7.0 5.0 100.0 Linear &H_CID1 15.0 5.0 100.0 Linear &H_CID2 15.0 5.0 100.0 Linear &H_CN1 15.0 5.0 100.0 Linear &H_CN2 15.0 5.0 100.0 Linear &H_hh1 7.0 5.0 100.0 Linear &H_hh2 7.0 5.0 100.0 Linear &H_HH1 15.0 5.0 100.0 Linear &H_HH2 15.0 5.0 100.0 Linear &H_PH11 15.0 5.0 100.0 Linear &H_PH12 15.0 5.0 100.0 Linear &H_PH21 15.0 5.0 100.0 Linear &H_PH22 15.0 5.0 100.0 Linear &alpha_wg11 1.0 1.0 10.0 Logarithmic &alpha_wg12 1.0 1.0 10.0 Logarithmic &alpha_wg21 1.0 1.0 10.0 Logarithmic &alpha_wg22 1.0 1.0 10.0 Logarithmic &beta_wg11 1.0 1.0 10.0 Logarithmic &beta_wg12 1.0 1.0 10.0 Logarithmic &beta_wg21 1.0 1.0 10.0 Logarithmic &beta_wg22 1.0 1.0 10.0 Logarithmic &Endo_WG1 0.001 0.001 1.0 Logarithmic &Endo_WG2 0.001 0.001 1.0 Logarithmic &Exo_WG1 0.1 0.01 10.0 Logarithmic &Exo_WG2 0.1 0.01 10.0 Logarithmic &Mxfer_WG1 0.001 0.001 1.0 Logarithmic &Mxfer_WG2 0.001 0.001 1.0 Logarithmic &LMxfer_WG1 0.1 0.001 1.0 Logarithmic &LMxfer_WG2 0.1 0.001 1.0 Logarithmic &LMxfer_PTC1 0.1 0.001 1.0 Logarithmic &LMxfer_PTC2 0.1 0.001 1.0 Logarithmic &LMxfer_HH1 0.1 0.001 1.0 Logarithmic &LMxfer_HH2 0.1 0.001 1.0 Logarithmic &endParameterValues &InitLevels &BackgroundLevel en1 0.0 &BackgroundLevel en2 0.0 &BackgroundLevel EN1 0.0 &BackgroundLevel EN2 0.0 &BackgroundLevel wg1 0.0 &BackgroundLevel wg2 0.0 &BackgroundLevel IWG1 0.0 &BackgroundLevel IWG2 0.0 &BackgroundLevel EWG1 0.0 &BackgroundLevel EWG2 0.0 &BackgroundLevel ptc1 0.0 &BackgroundLevel ptc2 0.0 &BackgroundLevel PTC1 0.0 &BackgroundLevel PTC2 0.0 &BackgroundLevel cid1 0.0 &BackgroundLevel cid2 0.0 &BackgroundLevel CID1 0.0 &BackgroundLevel CID2 0.0 &BackgroundLevel CN1 0.0 &BackgroundLevel CN2 0.0 &BackgroundLevel hh1 0.0 &BackgroundLevel hh2 0.0 &BackgroundLevel HH1 0.0 &BackgroundLevel HH2 0.0 &BackgroundLevel PH11 0.0 &BackgroundLevel PH12 0.0 &BackgroundLevel PH21 0.0 &BackgroundLevel PH22 0.0 &BackgroundLevel B 0.4 &ColumnIC &Node en1 &Value 1.0 &Column 2 &endIC &ColumnIC &Node en2 &Value 1.0 &Column 2 &endIC &ColumnIC &Node EN1 &Value 1.0 &Column 2 &endIC &ColumnIC &Node EN2 &Value 1.0 &Column 2 &endIC &ColumnIC &Node wg1 &Value 1.0 &Column 1 &endIC &ColumnIC &Node wg2 &Value 1.0 &Column 1 &endIC &ColumnIC &Node IWG1 &Value 1.0 &Column 1 &endIC &ColumnIC &Node IWG2 &Value 1.0 &Column 1 &endIC &endInitLevels &endNetwork