package affectors; import main.Globals; import main.Node; /** This is the third half of a heterodimerization between a membrane-bound and a cytoplasmic protein, leading to a cytoplasmic complex. Use this affector in the dimerized species. Use the A and B versions in the undimerized ones. Be careful to put the membrane and cytoplasmic species in the right order in the initializer. The node_scale you use for the dimer should be the scale for the undimerized protein least similar to the dimer (i.e. for ligand/receptor binding, you might use ligand0).
Formula
dDIMER/dt = r * max * MEMBRANE_NODE * CYTO_NODE
Parameters
Membrane Node [MEMBRANE_NODE] | The undimerized Node that is on the membrane |
Cytoplasmic Node [CYTO_NODE] | The undimerized Node that is in the cytoplasm |
Dimerization rate [r_DIMER] | The rate of the dimerization reaction. |
Maximum Cyto [max] | The maximum relative concentration of the undimerized Node less similar to the dimer. |
Usage
*/
public class DimerizeMemCyto_CAff extends Affector {
/** The rate of the dimerization reaction. */
int kParam;
/** The scaling factor of the other undimerized node in this reaction (i.e. max for second input node). */
int nodeScaleParam;
static final String desc = "Dimerize membrane-bound & cytoplasmic node; version C for dimer";
static final String [] nodeDescriptions = {"Membrane-bound node", "Cytoplasmic node"};
static final String [] paramDescriptions = {"Second-order reaction rate constant",
"Scale factor (max value) for least-similar node"};
static final int [] whichSides = {-1, -1};
public DimerizeMemCyto_CAff() {}
protected void setLabelsAndTypes() {
setDescriptions(this.desc, nodeDescriptions, paramDescriptions);
setSided(true, whichSides);
this.Type[GUI_CAPABLE] = 1;
this.Type[CERTIFICATION] = Affector.RETURNS_DERIV;
this.Type[MATHTYPE] = Affector.FF;
this.Type[TERMTYPE] = Affector.CONVERSION;
}
public void setParameterNumbers(int [] param_nums)
{
kParam = param_nums[0];
nodeScaleParam = param_nums[1];
}
public float getValue(Node which_node) {
return Globals.characteristicTime * params[kParam] * params[nodeScaleParam] * Nodes[0].getIntegrationValue() * Nodes[1].getIntegrationValue();
}
}
&DIMER
&DimerizeMemCyto_CAff MEMBRANE_NODE CYTO_NODE r_DIMER max
&endDIMER