package affectors; import main.Globals; import main.Node; /** This is one third of a heterodimerization between a membrane bound and a cytoplasmic protein, leading to a cytoplasmic complex. Use this affector in the undimerized, cytoplasmic species. Use the A version in the membrane bound undimerized species and the C version in the dimer. Be careful to put the membrane and cytoplasmic species in the right order in the initializer. The node_scale for each of the singleton proteins is the scaling factor for the >other< singleton (i.e. in the membrane node, give cytoNode0 as node_scale and vice-versa).

Formula
dCYTO_NODE/dt = - r * max_MEMBRANE_NODE * MEMBRANE_NODE * CYTO_NODE

Parameters
Membrane Node [MEMBRANE_NODE] The undimerized Node that is on the membrane
Cytoplasmic Node [CYTO_NODE] The undimerized Node that is in the cytoplasm
Dimerization rate [r_DIMER] The rate of the dimerization reaction.
Maximum Cyto [max_MEMBRANE] The maximum relative concentration of the membrane-bound Node.

Usage
&CYTO_NODE

&DimerizeMemCyto_BAff MEMBRANE_NODE CYTO_NODE r_DIMER max_MEMBRANE
&endCYTO_NODE */ public class DimerizeMemCyto_BAff extends Affector { /** The rate of the dimerization reaction. */ int kParam; /** The scaling factor of the other undimerized node in this reaction (i.e. max for membrane-bound node). */ int nodeScaleParam; static final String desc = "Dimerize membrane-bound & cytoplasmic node; version B for cytoplasmic node"; static final String [] nodeDescriptions = {"Membrane-bound node", "Cytoplasmic node"}; static final String [] paramDescriptions = {"Second-order rate constant", "Scale factor (max value) for most-similar node"}; static final int [] whichSides = {-1, -1}; public DimerizeMemCyto_BAff() {} protected void setLabelsAndTypes() { setDescriptions(this.desc, nodeDescriptions, paramDescriptions); setSided(true, whichSides); setContainsTarget(true); this.Type[GUI_CAPABLE] = 1; this.Type[CERTIFICATION] = Affector.RETURNS_DERIV; this.Type[MATHTYPE] = Affector.GG; this.Type[TERMTYPE] = Affector.CONVERSION; } public void setParameterNumbers(int [] param_nums) { kParam = param_nums[0]; nodeScaleParam = param_nums[1]; } public float getValue(Node which_node) { return -Globals.characteristicTime * params[kParam] * params[nodeScaleParam] * Nodes[0].getIntegrationValue() * Nodes[1].getIntegrationValue(); } public float getNCValue(Node which_node) { return -Globals.characteristicTime * params[kParam] * params[nodeScaleParam] * Nodes[0].getIntegrationValue(); } }